mullerk's Genetics Class

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3 années 5 mois ago

the main idea with the fungus is that it would be more difficult for mosquitoes to respond to compared to viruses or sterilization as it would cause starvation amongst the larvae, resulting in lower chances for survival amongst the mosquitoes variants, but the main concern is how it affects other water born microbes and larvae.

3 années 5 mois ago

I though this was a really cool article because it actually pairs really well with another student's article. Epigenetic alteration or modification is based on biochemical interactions caused by negative and positive feedback mechanisms which manipulate the synthesis of amino acids and the resulting conformation of polypeptides. All of the previously mentioned can have a drastic affect on gene expression in translation. Smoking is a prime example of a particular cause of an altered feedback mechanism which can affect gene expression and cause loss of control of cell growth which can eventually lead to cancer formation. Perhaps one of the ways we can study certain cancers, is by looking towards factors like smoking to understand how these habits affect our DNA and if the alterated gene expression can be corrected to prevent the formation of cancer.

3 années 5 mois ago

"You can always choose your own actions, but you can never choose their consequences".

You know when they say, smoking contains a myriad of toxins, ranging in the several thousands, it is really startling to discover how these chemicals can affect up to two generations ahead. As of recently the number of worldwide smokers has diminished, but the most popular time to smoke has just past within the last 60-80 years. This could mean members of two generations could have been affected by smoking if was it was done during the maternal great grandmother's pregnancy. This could also suggest that smoking can indirectly manipulate a person's genetic code and that interference can be passed from mother to offspring. I wonder, does it show similar results for second hand smoke?

3 années 5 mois ago

I do agree this is super interesting! Knowing that this protein can be yielded in such a way that it could be akin to something so common as a band aid provides relief as science advances. Having a grandma who suffered from diabetes, and as a result, many open wounds, this hits home because dressing those wounds and keeping the closest eye on them and the surrounding area was very difficult because of the nature of it; how susceptible it is to infection. I'm very glad this research is being done!

3 années 5 mois ago

This is actually really neat because it opens up a whole new world in terms of treatment and prevention for a range of cancers! Like a molecule on a microvessel that can be injected into the body that targets the specific gene related to the cancer. Then it could be individualized to be more aggressive, hopefully fending off the cancer and any future cancers.

3 années 5 mois ago

aids is one of the most mutatable virus in the world next to rhinovirus, also commonly known as the common cold, as it mutates to irreguraly to be permentaley cured or defended agains in the immune system.

3 années 5 mois ago

It is amazing to find out all the harmful side affects that smoking has on the body, I never would of thought that it could play a factor in causing autism. Especially since you always hear people's concerns about vaccines causing autism when it could be something you encounter every day. I am also intrigued as to why it skips a generation and seems to only affect females.

3 années 5 mois ago

This is fascinating research and another example of epigenetic influence on health of parents and their offspring. I just found an article entitled, “Cigarette Smoking and DNA methylation” (Lee & Pausova 2017). It links nicotine (as a carcinogen) and cancer. Also, our genetics class was just studying research whereby scientists ‘methylated’ the p16 gene, normally a tumor suppressor gene and made it a “methylation magnet.” This caused a higher incidence of spontaneous cancers in mice.

The carcinogens in cigarette smoke include: formaldehyde, chromium, polycyclic aromatic hydrocarbons and arsenic. These ingredients must cause DNA damage and could cause a myriad of epigenetic diseases like cancer and…autism.

Lee, Ken W. K., and Zdenka Pausova. “Cigarette Smoking and DNA Methylation.” Frontiers in Genetics 4 (2013): 132. PMC. Web. 12 May 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713237/

3 années 5 mois ago

This seems like a very interesting study. I have also had family members diagnosed with colorectal cancer and it is devastating. I wasn't aware that it is the second leading cause of death in men. I hope that they continue their research and perhaps find another treatment for cancer.

3 années 5 mois ago

I find this article interesting on multiple levels. Firstly, because I just so happen to be of European descent. And, secondly, because I also have a fascination with the human brain and how it works. We have traveled to space and landed on the moon, but don't understand the entirety of our own brains. Like many mental disorders and illnesses, we have little to no understanding on how they come about other than age seems to play a part, but not always. Hopefully, with more research into these similar SNPs, there can be a greater understanding into schizophrenia.

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