Targeting Osteosarcoma Cancer Stem Cells
by Msoy on April 6, 2017 - 11:56pm
Targeting the osteosarcoma cancer stem cell
Osteosarcoma is a rare form of cancer that develops in long solid bones like the distal femur and proximal tibia. Osteogenic sarcoma is posited to form from osteoprogenitor stem cells which have pursued alternative osteoblast differentiation pathways and cause the formation of malignant tumors, soft tissue masses and lastly osteoblast damage along the bone. Siclari et al. investigated the gene expression of osteosarcoma tumors in comparison to wild-type osteoblasts and discovered the heightened expression of RECQL4, SPP1, RUNX2, and IBSP, which were highly correlated with a depressed response to chemotherapy treatment in patients affected by osteogenic sarcoma. Recognizing that osteosarcoma CSC’s or cancer stem cells can reform and rejuvenate after a surgical or chemotherapy treatment, Siclari et al. proposed that future experiments be conducted in the interest of targeting the cancer stem cells as a method of osteosarcoma treatment post-op.
Although Osteosarcoma is relatively rare in comparison to other cancers, it is useful to understand the mechanism by which it forms as it could potentially lead to treatments for other forms of cancer. This disease usually affects young adults and children, is particularly aggressive, and has a mortality rate of approximately 25-50% depending on its progression. As such, it is crucial that a stronger treatment for Osteosarcoma is developed to ensure the survival of those affected are able to live a longer and more fulfilling life.
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2.) "What Is Osteosarcoma?" American Cancer Society. N.p., n.d. Web. 04 Apr. 2017.
3.) "Osteosarcoma." St. Jude Children's Research Hospital. N.p., n.d. Web. 04 Apr. 2017.