Cancer Drug Mechanisms

by klepeisj82 on May 9, 2017 - 11:30pm

Expression proteomics study to determine metallodrug targets and optimal drug combinations

 

The emerging technique termed functional identification of target by expression proteomics (FITExP) has been shown to identify the key protein targets of anti-cancer drugs. Here, we use this approach to elucidate the proteins involved in the mechanism of action of two ruthenium(II)-based anti-cancer compounds, RAPTA-T and RAPTA-EA in breast cancer cells, revealing significant differences in the proteins upregulated. RAPTA-T causes upregulation of multiple proteins suggesting a broad mechanism of action involving suppression of both metastasis and tumorigenicity.

I really was interested in this article for a couple of reasons. The world is being filled with all kinds of medicine, but what is going to make you sick and when your sick if you take something else will it make it worse. This article is about a system of treatment that can pick out the target proteins of anti-cancer drugs. They elucidate the proteins involved in the mechanism of action of two ruthenium(II)-based anti-cancer compounds, RAPTA-T and RAPTA-EA in breast cancer cells, revealing significant differences in between those that unregulated or not. The mechanism can be extremely helpful in testing acceptable combinations of Chemotherapy drugs. With sound information hopefully this will allow for more knowledge on Chemotherapy.

 

 

                                                References:

Ronald F. S. Lee,Alexey Chernobrovkin,Dorothea RutishauserClaire S. Allardyce,David HackerKai JohnssonRoman A. Zubarev Paul J. Dyson (8 May 2017) Expression proteomics study to determine metallodrug targets and optimal drug combinations Retrieved at May 9 2017 

Comments

Interesting. I am clad that research on the topic of cancer is continuous and that many techniques have been studied but unfortunately, none of them works out. I have also heard that breast cancer is associated with early menstrual cycle, late pregnancies and in those who don't breast feed. I wondered if those with higher RAPTA-T and RAPTA-EA have anything to do with those conditions....

Interesting. I am clad that research on the topic of cancer is continuous and that many techniques have been studied but unfortunately, none of them works out. I have also heard that breast cancer is associated with early menstrual cycle, late pregnancies and in those who don't breast feed. I wondered if those with higher RAPTA-T and RAPTA-EA have anything to do with those conditions....

Interesting. I am clad that research on the topic of cancer is continuous and that many techniques have been studied but unfortunately, none of them works out. I have also heard that breast cancer is associated with early menstrual cycle, late pregnancies and in those who don't breast feed. I wondered if those with higher RAPTA-T and RAPTA-EA have anything to do with those conditions....

Interesting. I am clad that research on the topic of cancer is continuous and that many techniques have been studied but unfortunately, none of them works out. I have also heard that breast cancer is associated with early menstrual cycle, late pregnancies and in those who don't breast feed. I wondered if those with higher RAPTA-T and RAPTA-EA have anything to do with those conditions....

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